A team of researchers from the Shanghai Institute of Ceramics, Chinese Academy of Sciences and the East China Normal University have developed polyvinyl pyrrolidone modified nanoparticles that serve as a deoxygenation agent against tumor cells. The therapy, which is described in Nature Nanotechnology, targeted cancer cells by cutting off the tumor’s blood supply to deprive and ‘suffocate’ tumor cells.
The agent is sensitive to changes in acid levels in the bloodstream, efficiently consumes oxygen and could create a product to aggregate and potentially block blood vessels, the team wrote. Preliminary work in mice models showed that the agent is biocompatible and establishes tumor hypoxia.
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