Researchers develop nanoparticle delivery system for gene editing tool

Researchers from the University of Massachusetts Amherst have designed a nanoparticle delivery system to assist the gene-editing tool known as CRISPR/Cas9 across the cell membrane and into the cell nucleus, effectively avoiding the cell’s natural defense mechanisms. The team’s work was published in ACS Nano.

“CRISPR has two components: a scissor-like protein called Cas9, and an RNA molecule called sgRNA that guides Cas9 to its target gene. Once the Cas9-sgRNA pair gets to the destination gene in the nucleus, it can interrogate its genetic mistakes and correct them with the help of the host cell’s repair machinery,” principal investigator Rubul Mout said in prepared remarks.

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