Topical immunotherapy combo effective against early skin cancer

Researchers from the Washington University School of Medicine and Harvard Medical School have shown that a combination of 2 topical drugs can trigger an immune response against precancerous skin lesions. The study was published yesterday in The Journal of Clinical Investigation.

The 2 drugs, calcipotriol and 5-fluorouracil, have been in use for years – topical 5-fluorouracil is prescribed to treat actinic keratosis. Calcipotriol is indicated by the FDA for psoriasis, an autoimmune disorder that presents with red, scaly patches of skin. The researchers combined the 2 drugs and evaluated the combination’s efficacy against actinic keratosis, a precursor to squamous cell carcinoma.

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